Identification of key therapeutic targets in nicotine-induced intracranial aneurysm through integrated bioinformatics and machine learning approaches
This study uncovers significant disruptions in metabolic and immune pathways in IA under nicotine influence, identifying TGFB1, MCL1, and CDKN1A as critical biomarkers. These findings offer a deeper understanding of IA's molecular mechanisms and potential therapeutic targets for nicotine-related toxicity.
Authors
- Qiang Ma (ORCID: https://orcid.org/0000-0002-7887-2031)
- Longnian Zhou
- Zhi Li (ORCID: https://orcid.org/0000-0002-0392-4140)
Institutions
- Hexi University (CN)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s40360-025-00921-3
- Citations
- 1
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 1.39