Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus

Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient ob/ob mice, leptin receptor-deficient db/db) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (RT1u) WOKW rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy.

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Publication Details

Journal
Neuroscience Research
Published
2025-04-17
DOI
https://doi.org/10.1016/j.neures.2025.04.002
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus

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Neuroscience Research
Neuroinflammation and Neurodegeneration Mechanisms
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Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus

Petra Baum, Matthias König, Joanna Kosacka, Michał Bulc, Thomas Ebert, Katarzyna Palus, Nora Klöting, Peggy Stock, Matthias Blüher, Sontje Krupka, Sabine Paeschke, Marcin Nowicki
article en

Abstract

Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient ob/ob mice, leptin receptor-deficient db/db) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (RT1u) WOKW rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy.

Neuroscience ResearchVol. 216
Helmholtz Centre for Environmental Research (DE), Leipzig University of Applied Sciences (DE), Cal Poly Humboldt (US), Helmholtz Zentrum München (DE), Humboldt-Universität zu Berlin (DE), University Hospital Leipzig (DE), Jena University Hospital (DE), University of Warmia and Mazury in Olsztyn (PL), Leipzig University (DE)
Deutsche Forschungsgemeinschaft
Good health and well-being
Openalex Percentile: Top 89%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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