Loss of melanocortin receptor accessory protein 2 in melanocortin-4 receptor neurons protect from obesity-associated autonomic and cardiovascular dysfunctions
These findings demonstrate that in addition to its role in energy balance and glucose homeostasis MRAP2 in MC4R neurons is crucial for cardiovascular autonomic regulation and is required for the development of obesity-associated hypertension and autonomic dysfunction.
Authors
- Julien A. Sebag (ORCID: https://orcid.org/0000-0002-8366-312X)
- Kamal Rahmouni (ORCID: https://orcid.org/0000-0001-5136-6748)
- Jon M. Resch (ORCID: https://orcid.org/0000-0002-5409-7771)
- Harald M. Stauss (ORCID: https://orcid.org/0000-0001-6647-1903)
- Hussein Herz (ORCID: https://orcid.org/0000-0003-0549-6298)
- Deniz Atasoy (ORCID: https://orcid.org/0000-0002-3325-8820)
- Alexis Olson
- Donald A. Morgan (ORCID: https://orcid.org/0000-0003-3167-1643)
- Paul A. Williams (ORCID: https://orcid.org/0000-0001-8824-2909)
- Deng‐Fu Guo (ORCID: https://orcid.org/0000-0001-7096-8613)
Institutions
- University of Iowa (US)
- Fraternal Order of Eagles (US)
- Arrowhead Pharmaceuticals (United States) (US)
- Iowa City VA Health Care System (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1093/cvr/cvaf067
- Citations
- 7
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 5.49
Funders
- National Institutes of Health
- Roy J. and Lucille A. Carver College of Medicine, University of Iowa