T cells of patients with systemic sclerosis or Sjögren’s disease display an aberrant metabolic state and memory phenotype in blood and lungs
In patients with SSc-ILD and SjD-ILD, a disturbed T-cell memory differentiation combined with an exhausted phenotype and reduced metabolic fitness point towards sustained T-cell receptor engagement and chronic stimulation. Thus, the retrieved data indicate a significant involvement of T cells in the disease pathology of SSc- and SjD-associated ILD.
Authors
- Jonas C. Schupp (ORCID: https://orcid.org/0000-0002-7714-8076)
- Ulrich Kalinke (ORCID: https://orcid.org/0000-0003-0503-9564)
- Benjamin Seeliger (ORCID: https://orcid.org/0000-0001-7373-752X)
- Theresa Graalmann (ORCID: https://orcid.org/0000-0003-1856-0981)
- Matteo Villa (ORCID: https://orcid.org/0000-0003-2684-0596)
- Christine Jänke
- Thea Thiele (ORCID: https://orcid.org/0000-0001-9197-0587)
- Torsten Witte
- Linus Maximillian Risser
- Christine Ehlers
- Hannah Biermann
Institutions
- Medical University of Graz (AT)
- Yale University (US)
- Medizinische Hochschule Hannover (DE)
- Helmholtz Centre for Infection Research (DE)
- German Center for Lung Research (DE)
- Center for Experimental and Clinical Infection Research (DE)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1093/rheumatology/keaf198
- Citations
- 1
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.47