One-Pot Stepwise Dechalcogenization of Trisulfides to Unsymmetrical Dialkyl Thioethers
The construction of C-S bonds has garnered significant interest due to the ubiquitous presence of organosulfur compounds in natural products and bioactive molecules. Herein, we report a one-pot, stepwise desulfuration strategy employing trisulfides as precursors for the synthesis of unsymmetrical dialkylthioethers. Our study demonstrates that copper powder facilitates the conversion of trisulfides into disulfides, which subsequently undergo a nickel-catalyzed reductive coupling to afford the desired products. This approach provides a practical, odorless, and broadly applicable method for the synthesis of unsymmetrical dialkylthioethers.
Authors
- Shun‐Yi Wang (ORCID: https://orcid.org/0000-0002-8985-8753)
- Weidong Rao (ORCID: https://orcid.org/0000-0002-6088-7278)
- Shusu Shen (ORCID: https://orcid.org/0000-0003-2307-999X)
- Ying Chen (ORCID: https://orcid.org/0000-0001-9128-1837)
- Fei Wang (ORCID: https://orcid.org/0000-0001-6428-5111)
- Ping Song (ORCID: https://orcid.org/0000-0001-5947-4604)
- Jiuwen Xu
Institutions
- Nanjing Forestry University (CN)
- Suzhou University of Science and Technology (CN)
- Laboratoire de Synthèse Organique (FR)
- Nanjing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1021/acs.orglett.5c01079
- Citations
- 1
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Cyrus Tang Foundation
- National Natural Science Foundation of China
- Soochow University
- Priority Academic Program Development of Jiangsu Higher Education Institutions