Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer’s disease
Our results highlighted that EPs can alleviate learning and memory impairments in AD with a gut microbiota-dependent manner and that butyric acid metabolized by butyric acid-metabolizing bacteria in the gut plays a central role in regulating brain glutamine metabolism to improve brain microenvironmental homeostasis. Meanwhile, the present study provides new insights into the treatment of AD with natural products.
Authors
- Penghao Sun
- Duoduo Ren
- Xuejun Chai (ORCID: https://orcid.org/0000-0002-5590-4328)
- Chenju Yi (ORCID: https://orcid.org/0000-0002-8686-4525)
- Xinrui Guo
- Yongkang Zhao
- Shanting Zhao (ORCID: https://orcid.org/0000-0002-5130-7315)
- Lulu Zhang (ORCID: https://orcid.org/0000-0001-6875-1538)
- Xiaoyan Zhu (ORCID: https://orcid.org/0000-0003-0821-7119)
- Wenxing Zhao
- Junlang Huang
Institutions
- Sun Yat-sen University (CN)
- North West Agriculture and Forestry University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Xi'an Medical University (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.jare.2025.04.025
- Citations
- 8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 6.45