Inhibition of renal fibrosis via Nrf2 activators for unilateral ureteral obstruction in a rat model
Nrf2 activators induced nuclear translocation and activation of Nrf2, resulting in upregulation of ARE-dependent genes. Although the function of Nrf2 in children is often unknown, this study may lead to future progress in oxidation and antioxidant function in children.
Authors
- Yayoi Murano (ORCID: https://orcid.org/0000-0003-4097-5104)
- Toshiaki Shimizu (ORCID: https://orcid.org/0000-0003-0364-0022)
- Yoshiyuki Ohtomo (ORCID: https://orcid.org/0000-0002-5436-143X)
- Mayu Nakagawa (ORCID: https://orcid.org/0000-0002-8814-6885)
- Amane Endo (ORCID: https://orcid.org/0000-0002-5994-8520)
- Koji Sakuraya (ORCID: https://orcid.org/0000-0003-0174-5728)
- Akira Mizutani
- Naoto Nishizaki (ORCID: https://orcid.org/0000-0001-9471-6146)
- Shuichiro Fujinaga (ORCID: https://orcid.org/0000-0002-2957-3705)
- Hiroki Miyano (ORCID: https://orcid.org/0009-0003-4930-4590)
Institutions
- Juntendo University (JP)
- Saitama Children's Medical Center (JP)
- Juntendo University Urayasu Hospital (JP)
- Juntendo University Nerima Hospital (JP)
Publication Details
- Journal
- Pediatrics International
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/ped.70000
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00