A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing
By eliminating the need for corneal scrapings and nucleic acid extraction, this tear-based method improves the timing and accuracy of bacterial pathogen diagnosis in corneal ulcers, allowing for prompt detection of causative organisms and enabling earlier targeted antimicrobial therapy, thereby improving patient outcomes.
Authors
- Jacob S. Heng (ORCID: https://orcid.org/0000-0001-6291-6688)
- Jessica Chow (ORCID: https://orcid.org/0000-0002-4798-4217)
- Mark Dibbs (ORCID: https://orcid.org/0000-0002-4341-361X)
- Despoina Theotoka (ORCID: https://orcid.org/0000-0001-9984-2360)
- Christine Y. Bakhoum (ORCID: https://orcid.org/0000-0002-7077-5472)
- Mathieu F. Bakhoum (ORCID: https://orcid.org/0000-0001-8989-8205)
- Yvonne Wang (ORCID: https://orcid.org/0000-0003-4946-1062)
- Christina Jayaraj (ORCID: https://orcid.org/0000-0001-8325-357X)
- Mitchelle Matesva (ORCID: https://orcid.org/0000-0003-3390-3698)
- Patrick Demkowicz (ORCID: https://orcid.org/0000-0002-9566-1033)
- Beruk Metiku (ORCID: https://orcid.org/0000-0003-3031-373X)
Institutions
- Yale Cancer Center (US)
- Yale University (US)
Publication Details
- Journal
- Translational Vision Science & Technology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1167/tvst.14.4.19
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- Melanoma Research Alliance
- National Institutes of Health
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases