The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice
Our findings highlight specific microglial subtypes as key regulators of cortical synapse development and plasticity through their interactions with PV(+) interneurons and PNNs. These insights advance our understanding of microglial contributions to visual cortex development and provide potential avenues for targeting microglial function to modulate cortical plasticity.
Authors
- Xin‐long Liu (ORCID: https://orcid.org/0000-0002-6223-2662)
- Yatu Guo (ORCID: https://orcid.org/0000-0001-7486-0044)
- Kuan Li (ORCID: https://orcid.org/0000-0002-5253-5811)
- Xuechun Wang (ORCID: https://orcid.org/0009-0001-5265-5856)
- Lingzhi Guo (ORCID: https://orcid.org/0000-0001-8183-4602)
- Wei Zhang
Institutions
- Tianjin University (CN)
- Nankai University (CN)
- Tianjin Medical University Eye Hospital (CN)
- Tianjin haihe hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1167/iovs.66.4.45
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Natural Science Foundation of China
- Nankai University
- Tianjin Science and Technology Program