Adipose mesenchymal stem cell-derived exosomes rescue mitochondrial function through SIRT1 to improve diabetic wound healing
These findings demonstrate that ADSC-exos promotes diabetic wound healing by restoring mitochondrial function and autophagy via SIRT1 activation. These findings highlight the therapeutic potential of ADSC-exos and provide a mechanistic foundation for future exosome engineering strategies.
Authors
- Juntao Han (ORCID: https://orcid.org/0000-0002-0407-4416)
- Jingtao Wei (ORCID: https://orcid.org/0000-0001-8260-1835)
- Xiaozhi Bai
- Peng Wang (ORCID: https://orcid.org/0000-0001-5889-1115)
- Yu Li (ORCID: https://orcid.org/0000-0001-6910-5933)
- Ting He (ORCID: https://orcid.org/0000-0002-3526-6656)
- Zhigang Xu
Institutions
- Xijing Hospital (CN)
Publication Details
- Journal
- Burns & Trauma
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/burnst/tkaf017
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shaanxi Province