Safeguarding genomic imprints in naive human pluripotency
Naive human pluripotent stem cells (hPSCs) closely mirror the pre-implantation epiblast but risk imprint erosion under strong MEK/ERK inhibition, jeopardizing disease modeling and regenerative applications. In Stem Cell Reports, Fischer et al. show that partial MEK/ERK inhibition plus ZFP57 overexpression crucially preserves parent-of-origin DNA methylation, thereby offering more faithful and stable naive hPSC models.
Authors
- Alejandro De Los Angeles (ORCID: https://orcid.org/0000-0001-9433-501X)
Institutions
- Broad Institute (US)
Publication Details
- Journal
- Stem Cell Reports
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.stemcr.2025.102475
- Citations
- 2
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61