First-in-Human Phase I/IIa Study of the First-in-Class CDK2/4/6 Inhibitor PF-06873600 Alone or with Endocrine Therapy in Patients with Breast Cancer

PF-06873600 demonstrated a benefit-risk profile consistent with the CDK4/6 inhibitor class of drugs, with preliminary clinical activity in hormone receptor+/HER2- metastatic breast cancer.

Authors

Institutions

Publication Details

Journal
Clinical Cancer Research
Published
2025-04-17
DOI
https://doi.org/10.1158/1078-0432.ccr-24-2740
Citations
7
Primary Topic
Advanced Breast Cancer Therapies
Type
article
Field-Weighted Citation Impact
10.63

Funders

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article

First-in-Human Phase I/IIa Study of the First-in-Class CDK2/4/6 Inhibitor PF-06873600 Alone or with Endocrine Therapy in Patients with Breast Cancer

Erika Hamilton, Maria Delioukina, Igor Bondarenko, Li Zhou et al.
7 citations
Clinical Cancer Research
Advanced Breast Cancer Therapies
10.63
article

First-in-Human Phase I/IIa Study of the First-in-Class CDK2/4/6 Inhibitor PF-06873600 Alone or with Endocrine Therapy in Patients with Breast Cancer

Erika Hamilton, Maria Delioukina, Igor Bondarenko, Li Zhou, Antoaneta Tomova, Jonathan Wade Goldman, Toshinari Yamashita, Komal L. Jhaveri, Allison Moreau, Heather Neumann, Yoichi Naito, Timothy Anthony Yap, Jessica Tougias, Feng Liu, Antonio Giordano, Jennifer Park, Shaveta Vinayak
article en
7 citations

Abstract

PF-06873600 demonstrated a benefit-risk profile consistent with the CDK4/6 inhibitor class of drugs, with preliminary clinical activity in hormone receptor+/HER2- metastatic breast cancer.

Clinical Cancer ResearchVol. 31(14)
APLA Health (US), Memorial Sloan Kettering Cancer Center (US), The University of Texas MD Anderson Cancer Center (US), Harvard University (US), University of California, Los Angeles (US), Pfizer (United States) (US), University of Washington (US), Cornell University (US), Medical University Plovdiv (BG), Kanagawa Prefectural Hospital Organization (JP), Kettering University (US), Connecting to Care (US), Fred Hutch Cancer Center (US), Sarah Cannon (US), Dana-Farber Cancer Institute (US), City Clinical Hospital (RU), Tennessee Oncology (US), National Cancer Center Hospital East (JP), La Jolla Pharmaceutical (United States) (US), Plovdiv University (BG), Kanagawa Cancer Center
Pfizer
Good health and well-being
Openalex Percentile: Top 2%
Advanced Breast Cancer Therapies
10.63
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