First-in-Human Phase I/IIa Study of the First-in-Class CDK2/4/6 Inhibitor PF-06873600 Alone or with Endocrine Therapy in Patients with Breast Cancer
PF-06873600 demonstrated a benefit-risk profile consistent with the CDK4/6 inhibitor class of drugs, with preliminary clinical activity in hormone receptor+/HER2- metastatic breast cancer.
Authors
- Erika Hamilton (ORCID: https://orcid.org/0000-0002-1911-0336)
- Maria Delioukina
- Igor Bondarenko (ORCID: https://orcid.org/0000-0002-7071-2471)
- Li Zhou (ORCID: https://orcid.org/0000-0002-9147-9357)
- Antoaneta Tomova
- Jonathan Wade Goldman (ORCID: https://orcid.org/0000-0002-4925-8243)
- Toshinari Yamashita (ORCID: https://orcid.org/0000-0002-6479-1660)
- Komal L. Jhaveri (ORCID: https://orcid.org/0000-0003-0472-1254)
- Allison Moreau
- Heather Neumann
- Yoichi Naito (ORCID: https://orcid.org/0000-0002-8490-9064)
- Timothy Anthony Yap (ORCID: https://orcid.org/0000-0002-2154-3309)
- Jessica Tougias
- Feng Liu (ORCID: https://orcid.org/0009-0003-9694-0602)
- Antonio Giordano (ORCID: https://orcid.org/0000-0002-7760-9717)
- Jennifer Park (ORCID: https://orcid.org/0000-0002-1269-739X)
- Shaveta Vinayak (ORCID: https://orcid.org/0000-0001-9197-7316)
Institutions
- APLA Health (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- Pfizer (United States) (US)
- University of Washington (US)
- Cornell University (US)
- Medical University Plovdiv (BG)
- Kanagawa Prefectural Hospital Organization (JP)
- Kettering University (US)
- Connecting to Care (US)
- Fred Hutch Cancer Center (US)
- Sarah Cannon (US)
- Dana-Farber Cancer Institute (US)
- City Clinical Hospital (RU)
- Tennessee Oncology (US)
- National Cancer Center Hospital East (JP)
- La Jolla Pharmaceutical (United States) (US)
- Plovdiv University (BG)
- Kanagawa Cancer Center
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2740
- Citations
- 7
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 10.63
Funders
- Pfizer