An Efficient Solvent‐Free, Catalyst‐Free Amination on Modified Nucleosides and One‐Pot Three‐Component Synthesis of 1,2,3‐Triazole‐Based Hybrid Nucleosides

An efficient catalyst‐free, solvent‐free amination reaction has been developed for the synthesis of various bioinspired 6‐substituted aminopurine nucleoside analogs in good yields. In this sustainable approach, unprotected 6‐substituted aminopurine nucleoside analogs are synthesized via amination reactions of unprotected 6‐Cl purine nucleosides with various amine derivatives. Notably, the method offers a simple, eco‐friendly, unifying protocol for the synthesis of various bioinspired molecules with highly functional group tolerance. Additionally, to demonstrate its synthetic applicability, a one‐pot, three‐component reaction protocol has been shown for the synthesis of novel 1,2,3‐triazole‐attached hybrid nucleosides containing various drug core moieties via click chemistry.