Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner
Our data demonstrate novel growth factor-controlled regulation of gene expression during direct fate conversion. This regulation is crucial for proper maturation of induced neurons and could be targeted to improve the repair process.
Authors
- Veronika Schwarz (ORCID: https://orcid.org/0000-0003-2528-257X)
- Juliane Merl‐Pham (ORCID: https://orcid.org/0000-0002-3422-4083)
- Lorenza Ronfani (ORCID: https://orcid.org/0000-0002-4602-3502)
- Marco Emilio Bianchi (ORCID: https://orcid.org/0000-0002-5329-6445)
- Finja Berger
- Priya Maddhesiya
- Stefanie M. Hauck (ORCID: https://orcid.org/0000-0002-1630-6827)
- Jovica Ninkovic (ORCID: https://orcid.org/0000-0002-4381-0041)
- Giacomo Masserdotti (ORCID: https://orcid.org/0000-0003-3621-3481)
- Tatiana Simon (ORCID: https://orcid.org/0000-0001-5686-8798)
- Tjaša Lepko
- Magdalena Götz (ORCID: https://orcid.org/0000-0003-1551-9203)
- Andrea Steiner-Mezzardi
- Júlia Schneider (ORCID: https://orcid.org/0000-0002-2128-7392)
- Anthodesmi Krontira
Institutions
- Vita-Salute San Raffaele University (IT)
- Center for Environmental Health (US)
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Genome biology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s13059-025-03556-z
- Citations
- 2
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Deutsche Forschungsgemeinschaft
- Fritz Thyssen Stiftung
- Ludwig-Maximilians-Universität München
- Helmholtz Zentrum München