<i>Lactococcus petauri</i> LZys1 modulates gut microbiota, diminishes ileal FXR-FGF15 signaling, and regulates hepatic function

This work elucidated the impact of <i>L. petauri</i> LZys1 on host gut microbiota metabolism and hepatic physiological metabolism. We observed that <i>L. petauri</i> LZys1 administration induced liver weight gain and biochemical parameters changes, in addition to a altered gut microbiota and suppressed bile acid (BA) profiles. Furthermore, we propose that changes in liver status are related to the enterohepatic farnesoid X receptor-fibroblast growth factor axis, which alters bile acid metabolism and disrupts liver function. The above findings suggest that attention should be paid to the effect of probiotics on liver function.