Melanin Nanoparticles as a Safe and Effective Iron Chelation Therapy: An ex vivo Assessment of Placental Transfer in Pregnant Beta-Thalassemia
It was demonstrated herein that transport of MNPs across the placental barrier is highly dependent on particle size (cut off size of 200 nm PEGylated MNPs). Findings suggest the possibility of providing a safe method of iron chelation during pregnancy. Future work using in vivo models will be applied to study systemic particle interactions.
Authors
- Toluwalase Awoyemi (ORCID: https://orcid.org/0000-0003-1542-9435)
- Helen Townley (ORCID: https://orcid.org/0000-0002-5369-7257)
- Manu Vatish (ORCID: https://orcid.org/0000-0002-6012-2574)
- Nahla Bakhamis
Institutions
- University of Oxford (GB)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijn.s494710
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63