Adjuvant Templating Improves On-Target/Off-Target Antibody Ratio Better than Linker Addition for M2-Derived Peptide Amphiphile Micelle Vaccines
While the linkers tested did not completely eliminate the production of off-target antibodies elicited by the PAMs, the inclusion of a Pam<sub>2</sub>CS moiety both increased the amount of on-target antibodies and improved the ratio of on-target to off-target antibodies in response to the M2<sub>2-16</sub> vaccine.
Authors
- Adam G. Schrum (ORCID: https://orcid.org/0000-0001-9276-1859)
- Bret D. Ulery (ORCID: https://orcid.org/0000-0003-0854-1859)
- Megan C. Schulte
- Agustin T. Barcellona
- Farnoushsadat Rezaei
- Adam C. Boll
- Natalie L. Conomos
Institutions
- University of Missouri (US)
Publication Details
- Journal
- Vaccines
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3390/vaccines13040422
- Citations
- 1
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- University of Missouri