Transcriptional Intermediary Factor 1γ–Induced Irisin in Skeletal Muscle Attenuates Renal Fibrosis in Diabetic Nephropathy
Our findings emphasize the potential of TIF1γ as a multitargeted therapeutic agent for DN, mitigating both renal and muscular complications through direct fibrosis inhibition and indirect myokine-mediated inter-organ crosstalk.
Authors
- Ha Nee Jang (ORCID: https://orcid.org/0000-0002-1402-931X)
- Hee Chang Jeon (ORCID: https://orcid.org/0000-0003-4275-4583)
- Myeong Hee Jung (ORCID: https://orcid.org/0000-0002-0787-2819)
- Hyo‐Soo Kim (ORCID: https://orcid.org/0000-0003-0847-5329)
- Jeong Won Yun
- Seunghye Lee (ORCID: https://orcid.org/0000-0001-8837-213X)
- Eun Ju Lee (ORCID: https://orcid.org/0000-0003-1773-0918)
- Hyun‐Jung Kim (ORCID: https://orcid.org/0000-0001-5883-4735)
- Jin Hyun Kim
- Sehyun Jung (ORCID: https://orcid.org/0000-0002-2510-8822)
- Se‐Ho Chang (ORCID: https://orcid.org/0000-0002-5278-0438)
Institutions
- Seoul National University (KR)
- Gyeongsang National University (KR)
- Seoul National University Hospital (KR)
- Gyeongsang National University Hospital (KR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/jcsm.13810
- Citations
- 4
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- National Research Foundation of Korea