Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on <i>CYP46A1</i> and <i>APOE</i> Genes.
Alterations in the expression of <i>APOE</i> and <i>CYP46A1</i> genes, as well as the expression of miRNAs regulating these genes, in astrocytes treated with Aβ suggests that the cell is attempting to modify the regulatory pathways of cholesterol homeostasis in the brain under pathological conditions, such as Alzheimer's disease.
Authors
- Maryam Adelipour (ORCID: https://orcid.org/0000-0002-5670-3595)
- Seyadeh Pardis Pezeshki
- Alireza Kheirollah (ORCID: https://orcid.org/0000-0002-8235-8190)
- Maryam Cheraghzadeh (ORCID: https://orcid.org/0000-0002-5271-0181)
- Zahra Nazeri (ORCID: https://orcid.org/0000-0002-4457-6285)
- Bahar Jaberian Asl (ORCID: https://orcid.org/0000-0003-0634-6697)
- Shirin Azizidoost (ORCID: https://orcid.org/0000-0002-6121-2176)
Institutions
- Dartmouth College (US)
- Ahvaz Jundishapur University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-03-22
- DOI
- https://doi.org/10.22074/cellj.2025.2029261.1587
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00