Long-Term retrospective analysis of retinal pigment epithelium atrophy and secondary hyperplasia following verteporfin photodynamic therapy

Verteporfin PDT rarely induces RPE atrophy in patients with wet AMD, PCV, and CSC. However, in patients with myopic CNV, PDT may occasionally cause alterations in the RPE, including both atrophy and secondary hyperplasia. While PDT-induced RPE atrophy was not a statistically significant predictor of best-corrected visual acuity at the final follow-up in the mCNV and wet AMD/PCV groups in the linear regression analysis, it was a significant factor in the CSC group.