Optimizing selectivity of the Cerebellar Cognitive Affective Syndrome Scale by use of correction formulas, and validation of its German version
The correction formulas improved diagnostic accuracy of the CCAS-Scale, particularly for the sum raw score. Therefore, we recommend using the corrected sum raw score for evaluation instead of the uncorrected number of failed items, proposed originally Hoche (Brain 141:248-270, 2018). Some test items, however, did not differentiate well between patients and controls and MDCs were large, highlighting the need for refined CCAS assessment instruments as progression or treatment outcomes.
Authors
- Imis Dogan (ORCID: https://orcid.org/0000-0002-6632-197X)
- Frank Konietschke (ORCID: https://orcid.org/0000-0002-5674-2076)
- Martina Minnerop (ORCID: https://orcid.org/0000-0003-1365-5236)
- Benedikt Frank (ORCID: https://orcid.org/0000-0001-8837-9489)
- Adam M. Berlijn (ORCID: https://orcid.org/0000-0002-5217-5860)
- Patricia Sulzer (ORCID: https://orcid.org/0000-0002-5952-7566)
- Kerstin Rubarth (ORCID: https://orcid.org/0000-0002-6174-6346)
- Johanna Müller (ORCID: https://orcid.org/0000-0001-5699-7047)
- Dana M. Huvermann (ORCID: https://orcid.org/0000-0002-9213-8335)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Kathrin Reetz (ORCID: https://orcid.org/0000-0002-9730-9228)
- Saskia Elben (ORCID: https://orcid.org/0000-0002-4214-4550)
- Raquel van der Veen
- Martin Köhrmann (ORCID: https://orcid.org/0000-0002-0701-9535)
- Jennifer Faber (ORCID: https://orcid.org/0000-0003-3265-0262)
- Julia-Elisabeth Aktories
- Dagmar Timmann (ORCID: https://orcid.org/0000-0003-1935-416X)
- Elke Wondzinski
- Heike Jacobi
- Friedrich Erdlenbruch (ORCID: https://orcid.org/0009-0006-0654-836X)
- Andreas Thieme (ORCID: https://orcid.org/0000-0001-6221-8601)
- Miriam Barkhoff
- Jürgen Konczak (ORCID: https://orcid.org/0000-0002-4422-5610)
- Giorgi Batsikadze (ORCID: https://orcid.org/0000-0002-0517-0119)
- Qi Liu (ORCID: https://orcid.org/0000-0003-0110-7750)
- Thomas Klockgether
- Sandra Röske
- Mario Siebler
Institutions
- University of Minnesota (US)
- University of Bonn (DE)
- Forschungszentrum Jülich (DE)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- University Hospital Heidelberg (DE)
- Essen University Hospital (DE)
- Jülich Aachen Research Alliance (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Duisburg-Essen (DE)
- Freie Universität Berlin (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1007/s00415-025-13083-3
- Citations
- 5
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Universitätsklinikum Essen
- European Commission
- Deutsche Forschungsgemeinschaft