Kilohertz High-Frequency Electrical Stimulation Effectively Mitigates Hyperalgesia in Mice With Neuropathic Pain Through Regulation of the Calcium/Calmodulin-Dependent Protein Kinase II/N-Methyl-D-Aspartate 2B Signaling Pathway
This study not only unveils the potential therapeutic value of KHES in treating neuropathic pain induced by CCI in mice but also provides insights into its molecular mechanisms of action through inhibition of the CaMKII/NMDAR2B signaling pathway.
Authors
- Bin Yu (ORCID: https://orcid.org/0000-0002-7218-7535)
- Wen Cheng (ORCID: https://orcid.org/0000-0003-3602-4138)
- Xiaorong Ouyang
- Kexin Fang
Institutions
- Tongji University (CN)
Publication Details
- Journal
- Neuromodulation Technology at the Neural Interface
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.neurom.2025.03.071
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China