Pentagalloyl glucose targets the JAK1/JAK3-STAT3 pathway to inhibit cancer stem cells and epithelial–mesenchymal transition in 5-fluorouracil-resistant colorectal cancer
PGG inhibit dual-target of CSCs and EMT via JAK1/JAK3-STAT3 signaling pathway in 5-FU-resistant CRC, providing a novel therapeutic approach to overcome chemoresistance.
Authors
- Gang Luo (ORCID: https://orcid.org/0000-0001-9650-4040)
- Nathupakorn Dechsupa (ORCID: https://orcid.org/0000-0002-0412-9659)
- Jiraporn Kantapan (ORCID: https://orcid.org/0000-0003-0480-3575)
- Chengli Wen (ORCID: https://orcid.org/0000-0001-8956-8898)
- Muhan Lü (ORCID: https://orcid.org/0000-0002-0527-3695)
- Sha Liu (ORCID: https://orcid.org/0000-0002-6710-8126)
- Hao Li (ORCID: https://orcid.org/0000-0001-7204-5898)
- Xu Zhang (ORCID: https://orcid.org/0009-0006-1742-0273)
- Wanmeng Xiao
- Sicheng Liang (ORCID: https://orcid.org/0000-0002-1191-1323)
- Zehui Yu (ORCID: https://orcid.org/0000-0003-0435-1548)
- Wei Yan (ORCID: https://orcid.org/0000-0002-2943-6065)
- Liping Yuan
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- First People’s Hospital of Zunyi (CN)
- Chiang Mai University (TH)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.phymed.2025.156773
- Citations
- 5
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 5.23