Exercise-induced extracellular vesicles delay tumor development by igniting inflammation in an immunologically cold triple-negative breast cancer mouse model
Our findings indicate that exercise-induced EV treatment elicits a pro-inflammatory antitumor immune response, suggesting a shift of immunologically cold TNBC tumors towards a more inflamed phenotype associated with better outcomes. Our study supports the further investigation of EVs as modulators of antitumor immunity and their potential utility in enhancing the efficacy of immunotherapy.
Authors
- Aija Linē (ORCID: https://orcid.org/0000-0002-8492-4758)
- Agata Mlynska (ORCID: https://orcid.org/0000-0002-3646-0258)
- Gabija Lukaseviciute
- Nijole Matuseviciene
- Krizia Sagini (ORCID: https://orcid.org/0000-0003-3357-2171)
- Alicia Llorente (ORCID: https://orcid.org/0000-0002-0045-071X)
- Silvana Romero
- Tomas Venckūnas (ORCID: https://orcid.org/0000-0002-1956-6616)
- Neringa Dobrovolskienė (ORCID: https://orcid.org/0000-0001-8044-8910)
- Vita Pašukonienė (ORCID: https://orcid.org/0000-0002-3395-1158)
- Karolina Suveizdė
- Beatriz Martin Gracia
- Austeja Butkute
- Beatrice Gudaite
Institutions
- Oslo University Hospital (NO)
- Lithuanian Sports University (LT)
- Latvian Biomedical Research and Study Centre (LV)
- Vilnius Gediminas Technical University (LT)
- National Cancer Institute (LT)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.jshs.2025.101041
- Citations
- 11
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 8.06