Pronounced effects of the sepsis–obesity paradox in elderly and male individuals without septic shock and the role of immune–inflammatory status: an analysis of MIMIC-IV data
The sepsis-obesity paradox significantly affects elderly (≥ 65 years old), male, and non-septic shock individuals, displaying a U-shaped pattern for 28-day mortality. BMI may mediate this phenomenon by influencing the body's immune-inflammatory status.
Authors
- Jun Ge (ORCID: https://orcid.org/0000-0002-3159-8573)
- Zhongrui Li (ORCID: https://orcid.org/0000-0001-5371-7628)
- Guoxuan Peng (ORCID: https://orcid.org/0000-0003-4580-7003)
- Ling Zeng (ORCID: https://orcid.org/0000-0002-6123-1924)
- R. Zhang (ORCID: https://orcid.org/0000-0001-5623-5229)
- Shunbin Luo (ORCID: https://orcid.org/0000-0002-7451-0463)
- Zhe Xu (ORCID: https://orcid.org/0000-0002-3338-4229)
- Jin Deng (ORCID: https://orcid.org/0000-0001-9968-1552)
- Chen Wang (ORCID: https://orcid.org/0000-0002-7164-3770)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Guiyang University (CN)
- The First People's Hospital of Guiyang (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s12879-025-10938-y
- Primary Topic
- Climate Change and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Centre Scientifique et Technique du Bâtiment
- Science and Technology Program of Guizhou Province