SIRT3 Represses Vascular Remodeling via Reducing Mitochondrial Ac-CoA Accumulation in Vascular Smooth Muscle Cells
This study provides evidence that mitochondrial dysfunction induced by SIRT3 inhibition is a major factor leading to VSMC phenotypic switching and vascular remodeling. Restoration of mitochondrial function and inhibition of mitochondrial Ac-CoA accumulation by activation of SIRT3 may help to treat remodeling-related cardiovascular damage.
Authors
- Zhencheng Yan (ORCID: https://orcid.org/0000-0001-5838-8376)
- Zongshi Lu (ORCID: https://orcid.org/0000-0002-2434-8832)
- Aidi Mou
- Min Sun (ORCID: https://orcid.org/0000-0001-9792-6798)
- Qing Zhou (ORCID: https://orcid.org/0000-0003-2316-5505)
- Peng Gao (ORCID: https://orcid.org/0000-0001-6145-7440)
- Min Liu (ORCID: https://orcid.org/0009-0002-9491-0891)
- Bowen Wang (ORCID: https://orcid.org/0000-0002-2974-9790)
- Lijuan Wang (ORCID: https://orcid.org/0000-0002-7786-4582)
- Zhiming Zhu (ORCID: https://orcid.org/0000-0001-6978-4155)
- Mei You
- Li Li (ORCID: https://orcid.org/0000-0003-0991-7897)
- Tingbing Cao
- Hongya Wang (ORCID: https://orcid.org/0000-0002-5409-9347)
Institutions
- Army Medical University (CN)
- Chinese Institute for Brain Research (CN)
- Hypertension Institute (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1161/atvbaha.125.322428
- Citations
- 4
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 4.90