Methodological limitations and confounders in dermal toxicity evaluation of aqueous test substance by OECD technical guidelines 402, 410: our experience of testing ethanol based hand sanitizer
In both the studies, ethanol based hand sanitizer (EBHS) was found to be non-irritant with LD<sub>50</sub> of > 2000 mg/kg and classified as Class 5/Unclassified according to GHS classification. Although, spongiotic changes were observed, methodological limitation of absence of control group in TG 402 and confounding effect of water and occlusion in all the animals/groups in both studies prevented us to attribute it to ethanol.
Authors
- Rajendra Palkhade (ORCID: https://orcid.org/0000-0001-7140-297X)
- Snehal P. Chavhan (ORCID: https://orcid.org/0000-0003-2103-3015)
- Jitendra Parmar
- Deepali Sammal
Institutions
- Norfolk State University (US)
- National Institute of Occupational Health (IN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1080/07853890.2025.2491664
- Citations
- 1
- Primary Topic
- Contact Dermatitis and Allergies
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Indian Council of Medical Research