Epigenetic Modulation of Vascular Smooth Muscle Cell Phenotype Switching in Early-Onset Acute Myocardial Infarction
This innovative epigenomic study into early-onset AMI not only identifies biomarkers associated with the disease and its mortality but also highlights the critical role of vascular smooth muscle cell phenotype regulation in early-onset AMI pathogenesis. Our findings suggest that changes in vascular smooth muscle cell phenotypes toward synthetic and osteoblast-like states play a crucial role in early-onset AMI.
Authors
- Hyojung Ryu (ORCID: https://orcid.org/0000-0002-2276-850X)
- Sang Yeub Lee (ORCID: https://orcid.org/0000-0003-1386-349X)
- Yoonsung Kwon (ORCID: https://orcid.org/0000-0002-7242-2734)
- Weon Kim (ORCID: https://orcid.org/0000-0003-1264-9870)
- Yeonsu Jeon (ORCID: https://orcid.org/0000-0003-4560-4142)
- Kyungwhan An (ORCID: https://orcid.org/0000-0001-9595-5130)
- Jin‐Yong Hwang (ORCID: https://orcid.org/0000-0002-6632-7239)
- Jong Bhak (ORCID: https://orcid.org/0000-0002-4228-1299)
- Sungwon Jeon (ORCID: https://orcid.org/0000-0002-2729-9087)
- Min Gyu Kang (ORCID: https://orcid.org/0000-0002-9672-1798)
- Yeo Jin Kim (ORCID: https://orcid.org/0000-0001-9122-914X)
- Eun‐Seok Shin (ORCID: https://orcid.org/0000-0002-9169-6968)
- Younghui Kang (ORCID: https://orcid.org/0000-0002-0323-0851)
- Jang‐Whan Bae (ORCID: https://orcid.org/0000-0003-1362-9804)
- Byoung-Chul Kim
Institutions
- Ulsan College (KR)
- Genome Research Foundation (KR)
- Kyung Hee University (KR)
- University of Ulsan (KR)
- Gyeongsang National University Hospital (KR)
- Kyung Hee University Dental Hospital (KR)
- Ulsan University Hospital (KR)
- Kyung Hee University Hospital at Gangdong (KR)
- Chung-Ang University Hospital (KR)
- Chungbuk National University Hospital (KR)
- Ulsan National Institute of Science and Technology (KR)
- Jisc (GB)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1161/atvbaha.125.322503
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61