Long‐term efficacy of 10 <scp>kHz</scp> spinal cord stimulation in managing painful diabetic neuropathy: A post‐study survey
High-frequency SCS at 10 kHz provided sustained and clinically meaningful improvements in pain and HRQoL for PDN patients at 4.1 years postimplantation, with no explants in the cohort due to inefficacy. Alongside these benefits, participants experienced metabolic changes that included reductions in body weight and HbA1c beyond that achieved at 24 months, although changes in lifestyle and medication were not accounted for in this analysis. Notably, the cohort's final mean EQ-5D-5L index score was comparable to the US norm. These findings support 10 kHz SCS as a durable and effective treatment option for PDN in routine clinical practice.
Authors
- Maged Guirguis (ORCID: https://orcid.org/0000-0003-4700-2698)
- Rose Province‐Azalde (ORCID: https://orcid.org/0000-0003-2866-5680)
- Dawood Sayed (ORCID: https://orcid.org/0000-0001-8867-2140)
- David DiBenedetto (ORCID: https://orcid.org/0000-0001-8116-3407)
- James Scowcroft
- Neel Mehta (ORCID: https://orcid.org/0000-0002-2761-7903)
- Shawn Sills (ORCID: https://orcid.org/0000-0001-9601-0657)
- Michael J. Jaasma (ORCID: https://orcid.org/0009-0006-4214-8945)
- Kasra Amirdelfan (ORCID: https://orcid.org/0000-0002-1209-7247)
- Deborah Edgar (ORCID: https://orcid.org/0009-0008-8371-168X)
- Khalid A. Sethi
- Thomas Stauss
- Manish Bharara (ORCID: https://orcid.org/0000-0002-1992-4110)
- Erika Petersen (ORCID: https://orcid.org/0000-0002-8548-1450)
- Jijun Xu (ORCID: https://orcid.org/0000-0002-5137-8199)
- Ali Nairizi
- Shivanand P. Lad (ORCID: https://orcid.org/0000-0003-4991-5319)
- Judith L. White
- Cong Yu
- Sarah Benducci
Institutions
- Cleveland Clinic (US)
- Ochsner Health System (US)
- University of Kansas (US)
- Duke University (US)
- Cornell University (US)
- Pain Management Institute (US)
- Swedish Medical Center (US)
- Kaiser Permanente Walnut Creek Medical Center (US)
- United Health Services (US)
- Nevro (United States) (US)
- Touchstone Research Laboratory (United States) (US)
- Weill Cornell Medicine (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Pain Practice
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1111/papr.70023
- Citations
- 5
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 10.95
Funders
- Eli Lilly and Company
- Cleveland Clinic
- Boston Scientific Corporation
- Saluda Medical
- SPR Therapeutics
- Nevro
- National Institutes of Health