Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study
Our study offers genetic evidence that supports a substantial causal relationship between CD and sepsis (28-day death in critical care). To enhance the specificity and objectivity of future research findings, it is recommended to specify the types of IBD and the severity of sepsis. Furthermore, the genetic risk loci related may become potential drug development targets.
Authors
- Longwei Xu (ORCID: https://orcid.org/0000-0001-7097-8299)
- Chengui Zhuo
- Ziting Liang (ORCID: https://orcid.org/0009-0008-2080-7676)
- Renyang Tong (ORCID: https://orcid.org/0000-0002-2429-6702)
- Ling Li (ORCID: https://orcid.org/0000-0002-0087-3034)
- Youyou Du (ORCID: https://orcid.org/0000-0002-5694-2844)
- Zhaohui Tong (ORCID: https://orcid.org/0000-0002-5341-6857)
- Ling Dao
- Lu Yu (ORCID: https://orcid.org/0009-0007-9449-8274)
- Xueyang Bai
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Taizhou Central Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s12920-025-02143-2
- Citations
- 2
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China