Nasopharyngeal Microbiota in South African Infants With Lower Respiratory Tract Infection: A Nested Case-Control Study of the Drakenstein Child Health Study
The associations between bacteria, viruses and LRTIs are similar to those from high-income countries. Haemophilus is a major bacterial driver of LRTIs, acting synergistically with viruses. Dolosigranulum and Corynebacterium may reduce LRTI risk, while Staphylococcus may reduce the risk of RSV-related LRTIs. CMV is associated with dysbiotic nasopharyngeal microbiota.
Authors
- Samantha Africa (ORCID: https://orcid.org/0000-0002-7688-7344)
- Veronica Allen (ORCID: https://orcid.org/0000-0002-3989-5513)
- Yao Xia (ORCID: https://orcid.org/0000-0002-5731-9413)
- William C. Nierman (ORCID: https://orcid.org/0000-0002-0425-9840)
- Shantelle Claassen-Weitz (ORCID: https://orcid.org/0000-0003-2175-3776)
- Lesley Jean Workman (ORCID: https://orcid.org/0000-0002-3433-6106)
- Kilaza Samson Mwaikono (ORCID: https://orcid.org/0000-0002-3598-7576)
- Fadheela Patel (ORCID: https://orcid.org/0000-0001-5177-7416)
- Sugnet Gardner‐Lubbe (ORCID: https://orcid.org/0000-0003-2762-9944)
- Lemese Ah Tow Edries
- Felix S. Dube (ORCID: https://orcid.org/0000-0003-2775-7786)
- Heather Joy Zar (ORCID: https://orcid.org/0000-0002-9046-759X)
- Stephanie Harris Mounaud
- Mark Patrick Nicol (ORCID: https://orcid.org/0000-0002-1366-4805)
- Luke Hannan (ORCID: https://orcid.org/0000-0002-8217-843X)
Institutions
- South African Medical Research Council (ZA)
- Edith Cowan University (AU)
- J. Craig Venter Institute (US)
- University of Cape Town (ZA)
- The University of Western Australia (AU)
- Dar es Salaam Institute of Technology (TZ)
- Stellenbosch University (ZA)
- Management Sciences (United States) (US)
- Red Cross War Memorial Children's Hospital (ZA)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1093/cid/ciaf184
- Citations
- 7
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- Bill and Melinda Gates Foundation
- National Research Foundation
- South African Medical Research Council
- University of Cape Town
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council