Bulk RNA-seq conjoined with ScRNA-seq analysis reveals the molecular characteristics of nucleus pulposus cell ferroptosis in rat aging intervertebral discs
This study reveals that ATF3 is a key driver of NP cell ferroptosis during IDD, and Rps6 +/Cxcl1- is a common molecular feature of ferroptotic NP cell subsets. These findings provide evidence and theoretical support for subsequent targeted intervention of NP cell ferroptosis, as well as provide directions for preventing and delaying IDD.
Authors
- Yue Zhou (ORCID: https://orcid.org/0000-0001-7102-6484)
- Shipeng Chen
- Chencheng Feng (ORCID: https://orcid.org/0000-0002-9393-304X)
- Xuezheng Ai
- Shiwu Dong (ORCID: https://orcid.org/0000-0002-5032-4893)
- Jiawei Fu
- Zhengbu Liao (ORCID: https://orcid.org/0000-0003-4591-9689)
- Chang Liu (ORCID: https://orcid.org/0000-0001-5219-1089)
- Yang Zhang (ORCID: https://orcid.org/0009-0006-3568-5769)
- Xue Leng
- Bo Huang (ORCID: https://orcid.org/0000-0002-6992-1102)
- Dan Long
- Jiang Long (ORCID: https://orcid.org/0009-0000-6048-0737)
- Changqing Li (ORCID: https://orcid.org/0000-0002-4254-7974)
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
- Chongqing Municipal Health Commission (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s13075-025-03550-7
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment