Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn’s disease
These findings demonstrated that AREG derived from Tregs and human intestinal MFs, induced by TGF-β, amplifies intestinal fibrotic reactions in experimental colitis as well as in human CD patients. Thus, the TGF-β-Smad3-AREG pathway could be a potential therapeutic target for treating fibrosis in CD.
Authors
- Junjian Sun (ORCID: https://orcid.org/0009-0000-8894-2497)
- Jiang Yu (ORCID: https://orcid.org/0000-0002-7550-5041)
- Chunhua Jiao (ORCID: https://orcid.org/0000-0001-6562-0516)
- Nana Tang (ORCID: https://orcid.org/0000-0002-4688-3043)
- Xiaojing Zhao (ORCID: https://orcid.org/0000-0001-5156-3864)
- Shu Wang (ORCID: https://orcid.org/0000-0002-8651-4795)
- Lu Wang (ORCID: https://orcid.org/0000-0001-9216-435X)
- Hongjie Zhang (ORCID: https://orcid.org/0000-0003-4497-0503)
- Jiajia Li (ORCID: https://orcid.org/0000-0003-1115-5131)
- Jingjing Ma (ORCID: https://orcid.org/0009-0000-9838-4345)
- Mingyuan Wang (ORCID: https://orcid.org/0000-0002-5931-6048)
- Junjie Lin
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s12967-025-06413-6
- Citations
- 8
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 14.54
Funders
- Cleveland Clinic
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Lerner Research Institute, Cleveland Clinic