Enantioselective and Regiodivergent Skeletal Transformations of 1,2,3-Thiadiazoles to Alkylidene Dihydrothiophenes
By leveraging the Rh-catalyzed asymmetric skeletal editing of 1,2,3-thiadiazoles, we successfully achieve the ligand-controlled enantioselective and regiodivergent synthesis of structurally diverse 2- and 3-alkylidene 2,3-dihydrothiophenes. Late-stage structural editing of complex natural and drug molecules is also enabled.
Authors
- You-Wei Chen (ORCID: https://orcid.org/0000-0001-9372-4320)
- Zhanhui Yang (ORCID: https://orcid.org/0000-0001-7050-8780)
- Hongguang Du (ORCID: https://orcid.org/0000-0003-3237-4261)
- Cunzhi Chen
- Jiaxi Xu (ORCID: https://orcid.org/0000-0002-9039-4933)
Institutions
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1021/acs.orglett.5c01067
- Citations
- 7
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- National Natural Science Foundation of China