Influence of transcranial electrical stimulation on repair processes in rats

The studies were carried out to study the effect of transcranial electrical stimulation of the antinociceptive system of the brain on the healing process of skin wounds in laboratory animals. Object of study: non-linear white male laboratory rats in the amount of 80 animals. In the first experimental group, a transcranial electrical stimulation mode was used in the form of a combination of direct and alternating currents with analgesic parameters. In the second and third experimental groups, the same combination was used, but with different pulse frequencies - 50 and 90 Hz («frequencies of non-analgesic stimulation»). Sessions of transcranial electrical stimulation were carried out once a day for 30 minutes for three days after the application of skin wounds. Additionally: for three days before the wound and three days after the operation («preventive» and “therapeutic» effects): both analgesic and non-analgesic modes of electrical influence were used. Under the influence of transcranial electrical stimulation with analgesic current parameters (frequency 70 Hz), a significant acceleration (by 21%) of the healing process and a reduction in the average time for complete wound healing are observed. Transcranial impacts with «non-analgesic stimulation frequencies» (50 and 90 Hz) did not cause any changes in the rate of healing, compared to the control. The greatest acceleration of wound healing under the influence of medical procedures is reliably manifested on days 4-7 after their application, and in the control group on days 10-11. In the «preventive» group, the change in wound size was significantly faster than that in rats with the «therapeutic» effect: on the 4th day, the difference in the area of wounds between the experimental groups and the control was statistically significant and amounted to 12%, while the «therapeutic» effect On the 8th day it achieves a similar result.