Effect of low-dose primaquine treatment on Plasmodium vivax recurrence and transmission-blocking activity in southwest Ethiopia: a longitudinal cohort study
This study demonstrate that with limited supervision of CQ + PQ treatment significantly lowers the risk of P. vivax recurrence in health clinics of southwest Ethiopia compared to CQ alone. Adding PQ to CQ also reduced P. vivax transmission to mosquito vectors relative to CQ alone but did not result in a complete transmission-blocking effect by day 42 post-treatment. Therefore, improved health education on treatment adherence and bed net use could enhance the effectiveness of PQ plus CQ. Higher doses of PQ for a shorter duration may be necessary to enhance treatment adherence, reduce recurrence rates, and decrease the risk of transmission.
Authors
- Hallelujah Getachew
- Ming‐Chieh Lee (ORCID: https://orcid.org/0000-0002-2462-6089)
- Xiaoming Wang (ORCID: https://orcid.org/0000-0003-1232-3125)
- Guiyun Yan (ORCID: https://orcid.org/0000-0001-8760-2925)
- Ashenafi Abossie
- Christopher L. King (ORCID: https://orcid.org/0000-0003-3873-7860)
- Kassahun Habtamu
- Delenasaw Yewhalaw (ORCID: https://orcid.org/0000-0002-2907-9360)
- Daibin Zhong (ORCID: https://orcid.org/0000-0002-2771-9598)
- Assalif Demissew (ORCID: https://orcid.org/0000-0001-7054-0641)
- Arega Tsegaye (ORCID: https://orcid.org/0000-0002-7985-9701)
- Teshome Degefa (ORCID: https://orcid.org/0000-0002-3518-2372)
- James W. Kazura
- Guofa Zhou
Institutions
- Jimma University (ET)
- University of California, Irvine (US)
- Ambo University (ET)
- Center for Global Health (US)
- Arba Minch University (ET)
- Menelik II Medical and Health Science College
- Addis Ababa University (ET)
- Case Western Reserve University (US)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s12936-025-05365-y
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Jimma University
- National Institutes of Health