Synergistic Induction of Immunogenic Cell Death by Biomineralized Manganese and Bisphosphonates Enhances Anti-PD-L1 Therapy in Triple-Negative Breast Cancer
MnHARis effectively synergizes Mn²<sup>+</sup> and Ris to promote autophagic apoptosis and ICD, increasing TILs and sensitizing TNBC to anti-PD-L1 therapy, thus offering a new therapeutic strategy.
Authors
- Ying Gu (ORCID: https://orcid.org/0000-0002-2870-2800)
- Qingbing Zheng (ORCID: https://orcid.org/0000-0002-7516-9965)
- Mingjing Wei (ORCID: https://orcid.org/0000-0002-2230-8693)
- Yanhua Lin (ORCID: https://orcid.org/0009-0000-0184-0755)
- Haibo Yu (ORCID: https://orcid.org/0000-0003-1506-2346)
- Lizhi Zhou (ORCID: https://orcid.org/0000-0001-6225-4303)
- Ningshao Xia (ORCID: https://orcid.org/0000-0003-0179-5266)
- Jun Zhang
- Xiuli Zhang (ORCID: https://orcid.org/0000-0001-7854-6466)
- Tingting Li (ORCID: https://orcid.org/0000-0001-9209-0602)
- Shaowei Li (ORCID: https://orcid.org/0000-0002-3374-1038)
- Yufang Li (ORCID: https://orcid.org/0000-0002-7428-9615)
- Yarong Zeng
- Nan Liu (ORCID: https://orcid.org/0009-0008-0767-9788)
- Chuanlai Yang
Institutions
- Xiamen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Vaccine and Serum Institute (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijn.s502394
- Citations
- 3
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 2.02