Efficacy of adjuvant use of midodrine in patients with septic shock: An open label randomized controlled trial

The findings did not demonstrate a significant reduction in mortality with adjuvant midodrine use in the treatment of septic shock. Midodrine appears to reduce the need for vasopressors. However, our findings did not support that midodrine shortens the duration of vasopressor use nor the course of hospitalization for patients with septic shock.

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Publication Details

Journal
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
Published
2025-04-16
DOI
https://doi.org/10.1002/phar.70018
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Efficacy of adjuvant use of midodrine in patients with septic shock: An open label randomized controlled trial

Moetaza M. Soliman, Adel Al‐Hady Ahmed Diab, Noha O. Mansour, Nadine K. El‐Nagdy
1 links
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
Sepsis Diagnosis and Treatment
article

Efficacy of adjuvant use of midodrine in patients with septic shock: An open label randomized controlled trial

Moetaza M. Soliman, Adel Al‐Hady Ahmed Diab, Noha O. Mansour, Nadine K. El‐Nagdy
article en

Abstract

The findings did not demonstrate a significant reduction in mortality with adjuvant midodrine use in the treatment of septic shock. Midodrine appears to reduce the need for vasopressors. However, our findings did not support that midodrine shortens the duration of vasopressor use nor the course of hospitalization for patients with septic shock.

Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyVol. 45(5)
Mansoura University (EG), Al-Azhar University (EG), Delta University for Science and Technology (EG)
Good health and well-being
Openalex Percentile: Top 89%
Sepsis Diagnosis and Treatment
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