The conclusiveness of trial sequential analysis varies with estimation of between-study variance: a case study
This study highlights the importance of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mover><mml:mi>τ</mml:mi> <mml:mo>^</mml:mo></mml:mover> </mml:math> <sup>2</sup> in trial sequential analysis and underscores the need to align the meta-analysis and the trial sequential analysis by choosing estimators to avoid introducing biases and discrepancies in effect size estimates and uncertainty assessments.
Authors
- James S. Hodges (ORCID: https://orcid.org/0000-0001-7467-6941)
- Enoch Kang (ORCID: https://orcid.org/0000-0002-4903-942X)
- Yu‐Chieh Chuang (ORCID: https://orcid.org/0000-0002-7124-6556)
- Chiehfeng Chen (ORCID: https://orcid.org/0000-0002-1595-6553)
- Jin-Hua Chen
Institutions
- University of Minnesota (US)
- National Taiwan University (TW)
- Taipei Medical University Hospital (TW)
- Taipei City Hospital (TW)
- Wan Fang Hospital (TW)
- Minnesota Department of Health (US)
- Taipei Medical University (TW)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s12874-025-02545-x
- Citations
- 1
- Primary Topic
- Meta-analysis and systematic reviews
- Type
- article
- Field-Weighted Citation Impact
- 1.40