Updates in Liver Transplantation for Alcohol-Related Liver Disease

The prevalence of alcohol use disorder (AUD) and alcohol-related liver disease (ALD) has increased in the last two decades. ALD is currently the most common indication for both waitlist additions and liver transplant (LT) in the United States, including alcohol-associated cirrhosis, alcohol-associated hepatitis (AH), and acute-on-chronic liver failure (ACLF). ALD also has a significant global disease burden. LT in ALD is a complex paradigm that poses both medical and ethical challenges, requiring a multidisciplinary approach to management. Furthermore, the scope of liver transplantation for alcohol use is expanding. Here we review updates in LT for ALD pertinent for the practicing clinician. We will discuss current practice patterns, treatment strategies, and outcomes.