A phase 2 PBTC study of selumetinib for recurrent/progressive pediatric low-grade glioma: Strata 2, 5, and 6 with long-term outcomes on strata 1, 3, and 4
Selumetinib provided stability and responses across many pLGG subgroups, and some patients achieved prolonged disease control without additional therapy.
Authors
- Tina Young Poussaint (ORCID: https://orcid.org/0000-0002-0814-0791)
- Jason Fangusaro (ORCID: https://orcid.org/0000-0003-3099-5259)
- Daniel Landi (ORCID: https://orcid.org/0000-0002-1487-1136)
- Natasha Pillay‐Smiley
- Nathan Robison (ORCID: https://orcid.org/0000-0001-8613-9772)
- Azra H. Ligon (ORCID: https://orcid.org/0000-0001-7585-2441)
- Anuradha Banerjee (ORCID: https://orcid.org/0000-0002-1694-4319)
- Alicia Lenzen (ORCID: https://orcid.org/0000-0002-9123-419X)
- Clinton F. Stewart (ORCID: https://orcid.org/0000-0002-1546-9720)
- Lindsay Kilburn (ORCID: https://orcid.org/0000-0003-1478-3619)
- Ibrahim A. Qaddoumi (ORCID: https://orcid.org/0000-0002-6645-4895)
- Sonia Partap (ORCID: https://orcid.org/0000-0001-5615-7689)
- Arzu Onar‐Thomas (ORCID: https://orcid.org/0000-0003-1005-2413)
- Shelly Lensing (ORCID: https://orcid.org/0000-0002-6231-9362)
- Maryam Fouladi (ORCID: https://orcid.org/0000-0002-5693-035X)
- Ira J. Dunkel (ORCID: https://orcid.org/0000-0001-8091-6067)
- Ian F. Pollack (ORCID: https://orcid.org/0000-0003-1765-357X)
- David Jones (ORCID: https://orcid.org/0000-0002-2036-5141)
- Neal Lindeman
Institutions
- Brigham and Women's Hospital (US)
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Lurie Children's Hospital (US)
- St. Jude Children's Research Hospital (US)
- Nationwide Children's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Children's Hospital of Los Angeles (US)
- Harvard University (US)
- Emory University (US)
- University of Pittsburgh (US)
- Palo Alto University (US)
- German Cancer Research Center (DE)
- Cornell University (US)
- Heidelberg University (DE)
- Center for Cancer and Blood Disorders (US)
- Aflac (United States) (US)
- Hopp Children's Cancer Center Heidelberg (DE)
- Lurie Children's Hospital (US)
- Children's Hospital of Pittsburgh (US)
- UCSF Benioff Children's Hospital (US)
- Stanford Medicine (US)
- Children's Healthcare of Atlanta (US)
- Pediatric Brain Tumor Foundation (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1093/neuonc/noaf065
- Citations
- 9
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 12.50