Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling
Our findings reveal that NMN promotes FGSC proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling. These results deepen our understanding of FGSC proliferation and highlight potential therapeutic avenues for advancing FGSC applications in reproductive medicine.
Authors
- Yujie Liu (ORCID: https://orcid.org/0000-0001-9385-0255)
- Hong Zhou (ORCID: https://orcid.org/0000-0003-0120-3347)
- Ji Wu (ORCID: https://orcid.org/0000-0002-6424-9783)
- Geng Tian
Institutions
- Shanghai Jiao Tong University (CN)
- Ministry of Education (ME)
- Ningxia Medical University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1186/s13578-025-01387-w
- Citations
- 2
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Shanghai Jiao Tong University
- National Key Research and Development Program of China