Proteogenomic Analysis of Healthy and Cancerous Prostate Tissues Using SILAC and Mutation Databases
Prostate cancer is the second most diagnosed cancer in men worldwide and a significant cause of cancer-related death. Proteogenomic analysis offers insights into how genomic mutations influence protein expression and can identify novel biomarkers. This study aimed to investigate the impact of missense mutations on protein abundance in prostate cancer versus healthy tissues using SILAC-based quantitative proteomics.
Authors
- Ricardo Alves da Silva (ORCID: https://orcid.org/0000-0002-7185-1852)
- Themistocles Yure Ferreira Silva
- Lucas Marques da Cunha (ORCID: https://orcid.org/0000-0003-1555-2505)
- Thiago Lopes Nascimento
- Rafaela Marie Melo da Cunha
- Giullia de Souza Santos
Publication Details
- Journal
- Oncology Advances
- Published
- 2025-03-30
- DOI
- https://doi.org/10.14218/ona.2024.00032
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Internacional de La Rioja
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul