Circulating Tissue Specific Extracellular Vesicles for Noninvasive Monitoring of Acute Cellular Rejection in Clinical Heart Transplantation
Our first investigation in heart transplant patients demonstrated that circulating T cell-sEV and donor heart-sEV profiles enable diagnosis of moderate ACR with high diagnostic accuracy. A large sample cohort external validation study is warranted to better understand diagnostic potential of this platform for ACR monitoring in heart transplantation.
Authors
- Robert W. Hu (ORCID: https://orcid.org/0000-0001-6366-3870)
- Laxminarayana Korutla (ORCID: https://orcid.org/0009-0007-0615-0594)
- Christopher Maulion (ORCID: https://orcid.org/0000-0002-2510-4266)
- Abdulelah Nuqali (ORCID: https://orcid.org/0000-0002-4992-607X)
- Sudheer K. Molugu (ORCID: https://orcid.org/0000-0001-9939-1950)
- Parisa Abedi
- Connie Romano (ORCID: https://orcid.org/0009-0007-9104-5122)
- Zuoheng Wang (ORCID: https://orcid.org/0000-0002-7251-3687)
- Andreas Habertheuer (ORCID: https://orcid.org/0000-0001-7310-8838)
- Prashanth Vallabhajosyula (ORCID: https://orcid.org/0000-0002-1192-3367)
- Sounok Sen (ORCID: https://orcid.org/0000-0002-1806-3566)
- Susan Rostami (ORCID: https://orcid.org/0009-0004-4791-9281)
- Michael Beasley
- Samuel Hahn
- Ali Naji (ORCID: https://orcid.org/0000-0002-6926-3306)
- He Wang (ORCID: https://orcid.org/0000-0001-9736-8028)
- Tariq Ahmad (ORCID: https://orcid.org/0000-0001-7596-4697)
- Yihan Liu
Institutions
- Creighton University (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Yale University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Transplantation
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1097/tp.0000000000005369
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61