TSP-1-CD47-integrin α4β1 axis drives T cell infiltration and synovial inflammation in rheumatoid arthritis
The three-molecule model of "TSP-1, CD47 and integrin α4β1" confirmed that CD47 plays an important role in the occurrence and progression of collagen-induced arthritis, a typical animal model of rheumatoid arthritis. Blocking the TSP-1-CD47 interaction or inhibiting CD47-activated integrin α4β1 on T cells could be a potential therapeutic strategy for rheumatoid arthritis.
Authors
- Weiyan Qi (ORCID: https://orcid.org/0000-0003-2756-7798)
- Xinmin Wang (ORCID: https://orcid.org/0000-0003-1675-327X)
- Jialiang Hu (ORCID: https://orcid.org/0000-0002-6630-1514)
- Yaoyao Wang (ORCID: https://orcid.org/0000-0001-5237-378X)
- Wing‐Yan Lai
- Chuang Ge
- Hanmei Xu
- Wei Ji (ORCID: https://orcid.org/0000-0001-7091-2759)
- Zeqing Li (ORCID: https://orcid.org/0000-0002-6294-6243)
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Inner Mongolia University of Science and Technology (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1524304
- Citations
- 2
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.59