Assessing HIV-1 subtype C infection dynamics, therapeutic responses and reservoir distribution using a humanized mouse model
In this preliminary study, discernible differences were noted between HIV-1C and B with implications for prevention, therapeutics and curative strategies. Results from here also highlight the utility of the hu-HSC mouse model for future expanded studies in this context.
Authors
- Jyoti Sutar (ORCID: https://orcid.org/0000-0002-5869-2156)
- Tushar Pandey (ORCID: https://orcid.org/0000-0002-0829-0263)
- Snehal Kaginkar (ORCID: https://orcid.org/0000-0001-7200-2951)
- Sivasankar Panickan (ORCID: https://orcid.org/0000-0001-5649-727X)
- Leila Remling‐Mulder
- Ramesh Akkina (ORCID: https://orcid.org/0000-0002-1577-5154)
- Elizabeth D. Barnett (ORCID: https://orcid.org/0000-0003-4822-5949)
- Vainav Patel (ORCID: https://orcid.org/0000-0001-6661-3238)
- Annapurna Sahoo (ORCID: https://orcid.org/0000-0002-5079-0261)
- Amit Kumar Singh (ORCID: https://orcid.org/0000-0002-1913-1129)
- Pranay Gurav
Institutions
- National Institute for Research in Reproductive Health (IN)
- Translational Health Science and Technology Institute (IN)
- Colorado State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1552563
- Citations
- 2
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.07
Funders
- Wellcome Trust
- Department of Biotechnology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- University Grants Commission
- The Wellcome Trust DBT India Alliance
- National Institutes of Health