Raman liquid biopsy: a new approach to the multiple sclerosis diagnostics
Using the above methods, we have obtained possibility to separate persons with multiple sclerosis and healthy ones with an average specificity of 0.96 and an average sensitivity of 0.89. The main Raman bands for discrimination against multiple sclerosis and healthy individuals are 632, 721-735, 1,048-1,076 cm<sup>-1</sup>. In general, the study of the spectral properties of blood serum using surface enhanced Raman spectroscopy is a promising method for diagnosing multiple sclerosis, however, further detailed studies in this area are required.
Authors
- Natalia Shusharina (ORCID: https://orcid.org/0000-0002-8848-6134)
- Matvey Khoymov (ORCID: https://orcid.org/0000-0001-8056-2019)
- A. F. Zakharov (ORCID: https://orcid.org/0000-0003-2387-6964)
- Anna V. Neupokoeva
- Lyudmila A. Bratchenko (ORCID: https://orcid.org/0000-0003-3781-9274)
- Valery P. Zakharov (ORCID: https://orcid.org/0000-0002-0597-3122)
- Ivan А. Bratchenko (ORCID: https://orcid.org/0000-0003-3629-7064)
- Elena Khivintseva (ORCID: https://orcid.org/0000-0002-1878-7951)
- Igor V. Shirolapov (ORCID: https://orcid.org/0000-0002-7670-6566)
Institutions
- Immanuel Kant Baltic Federal University (RU)
- Samara National Research University (RU)
- Samara State Medical University (RU)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fneur.2025.1516712
- Citations
- 1
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 1.63