Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice
Quercetin supplementation alleviates obesity by restoring high-fat diet induced gut microbiota disorder, which elevates IPA level to activate AhR/IL-22 pathway, thereby enhancing intestinal barrier integrity and suppressing chronic inflammation.
Authors
- Qingjun Guo (ORCID: https://orcid.org/0009-0007-7299-4525)
- Yunyan Yang (ORCID: https://orcid.org/0000-0002-9520-6639)
- Jiaheng Lu (ORCID: https://orcid.org/0000-0003-2067-454X)
- Huifan Yang (ORCID: https://orcid.org/0000-0002-1874-4863)
- Lijie Su (ORCID: https://orcid.org/0000-0003-3631-4346)
- Jiayu Xie
- Yanting Huang (ORCID: https://orcid.org/0000-0002-3024-8942)
- Yujing Zhang (ORCID: https://orcid.org/0000-0001-8451-2035)
- Jing Chen (ORCID: https://orcid.org/0000-0002-1088-0019)
Institutions
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fnut.2025.1574792
- Citations
- 12
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 13.97