Multigene Detection Analysis of Multifocal Papillary Thyroid Carcinoma
Multi-gene panel testing of preoperative FNAB samples effectively discriminates clonal relationships in MPTC, revealing distinct molecular profiles between ITM and IP. The high prevalence of BRAF V600E mutations and frequent clonal homogeneity underscore the necessity of comprehensive genetic profiling to guide personalized management. Routine multi-lesion sampling is advocated for optimizing risk stratification and surgical decision-making.
Authors
- Xiaolian Fang (ORCID: https://orcid.org/0000-0003-2862-9620)
- Zhentian Kai (ORCID: https://orcid.org/0000-0002-7934-9285)
- Pingdong Li (ORCID: https://orcid.org/0000-0002-1528-1736)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0001-6832-5416)
- Peng Luo (ORCID: https://orcid.org/0009-0008-5488-7483)
- Junwei Huang (ORCID: https://orcid.org/0000-0002-8182-9448)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Zhejiang Medicine (China) (CN)
Publication Details
- Journal
- Clinical Endocrinology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1111/cen.15251
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00