Multi-omics landscape of alternative splicing in diffuse midline glioma reveals immune- and neural-driven subtypes with implications for spliceosome-targeted therapy
Our findings indicate that H3K27-altered DMG exhibits significant alternative splicing alterations, which play crucial roles in tumorigenesis and progression. Additionally, our study identified an RNA-binding protein-based classification of DMG and characterized <i>RALYL</i> as a potential regulatory factor, highlighting its potential as a novel therapeutic target.
Authors
- Chaxian Liu
- Chufan Zhang (ORCID: https://orcid.org/0000-0002-7563-0512)
- Hao Lin
- Xiaomin Fan (ORCID: https://orcid.org/0000-0002-4553-9670)
- Haikun Song (ORCID: https://orcid.org/0000-0001-9125-3377)
- Yue Liu (ORCID: https://orcid.org/0000-0002-5625-0602)
- Hui Yang (ORCID: https://orcid.org/0000-0001-7278-4965)
- Ying Mao (ORCID: https://orcid.org/0000-0001-8055-115X)
- Bilong Zhang
- Yi Lyu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1587009
- Citations
- 2
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- National Key Research and Development Program of China